Originally featured as a boss in Mortal Kombat: Shaolin Monks, the Giant Serpent was used by the Saurian known as Reptile as a weapon within his lair. Reptile refers to the creature as his pet. It was eventually defeated by Liu Kang and Kung Lao.

The creature later reappeared in Mortal Kombat: Armageddon, but only as a statue seen in the background of Reptile's Lair. According to unlockable concept art available in the game's Krypt, the Giant Serpent was once intended to be alive in the arena^[1], featured as a death trap that would eat any players who were knocked into its mouth. However, the artwork's description states, "the great serpent died before the game was finished and a statue was built in it's (sick) honor."^[2] The many giant eggs surrounding the arena are described as being Giant Serpent eggs.^[3]

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