Originally featured as a boss in Mortal Kombat: Shaolin Monks, the Giant Serpent was used by the Saurian known as Reptile as a weapon within his lair. Reptile refers to the creature as his pet. It was eventually defeated by Liu Kang and Kung Lao.
The creature later reappeared in Mortal Kombat: Armageddon, but only as a statue seen in the background of Reptile's Lair. According to unlockable concept art available in the game's Krypt, the Giant Serpent was once intended to be alive in the arena, featured as a death trap that would eat any players who were knocked into its mouth. However, the artwork's description states, "the great serpent died before the game was finished and a statue was built in it's (sic) honor." The many giant eggs surrounding the arena are described as being Giant Serpent eggs.